Constitutive MAP kinase activation in hematopoietic stem cells induces a myeloproliferative disorder
Constitutive MAP kinase activation in hematopoietic stem cells induces a myeloproliferative disorder
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPNs) are a group of myeloid neoplasms in which abnormal activation of the Ras signaling pathway is commonly observed. The PI3K/Akt pathway is a known target of Ras; however, activation of the PI3K/Akt pathway has been shown to lead to neoplastic transformation of not only myeloid but also...
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Constitutive MAP kinase activation in hematopoietic stem cells induces a myeloproliferative disorder
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TN_cdi_plos_journals_1311365698
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1311365698
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0028350
