Nicotinamide Inhibits Alkylating Agent-Induced Apoptotic Neurodegeneration in the Developing Rat Bra...
Nicotinamide Inhibits Alkylating Agent-Induced Apoptotic Neurodegeneration in the Developing Rat Brain
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Exposure to the chemotherapeutic alkylating agent thiotepa during brain development leads to neurological complications arising from neurodegeneration and irreversible damage to the developing central nerve system (CNS). Administration of single dose of thiotepa in 7-d postnatal (P7) rat triggers activation of apoptotic cascade and widespread neuro...
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Full title
Nicotinamide Inhibits Alkylating Agent-Induced Apoptotic Neurodegeneration in the Developing Rat Brain
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TN_cdi_plos_journals_1311701112
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1311701112
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0027093
