Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau tr...
Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice
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Author / Creator
Bi, Mian , Ittner, Arne , Ke, Yazi D , Götz, Jürgen and Ittner, Lars M
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
In Alzheimer's disease (AD) brains, the microtubule-associated protein tau and amyloid-β (Aβ) deposit as intracellular neurofibrillary tangles (NFTs) and extracellular plaques, respectively. Tau deposits are furthermore found in a significant number of frontotemporal dementia cases. These diseases are characterized by progressive neurodegeneration,...
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Full title
Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice
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TN_cdi_plos_journals_1311704980
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1311704980
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0026860
