A Convenient Model of Severe, High Incidence Autoimmune Gastritis Caused by Polyclonal Effector T Ce...
A Convenient Model of Severe, High Incidence Autoimmune Gastritis Caused by Polyclonal Effector T Cells and without Perturbation of Regulatory T Cells
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Autoimmune gastritis results from the breakdown of T cell tolerance to the gastric H(+)/K(+) ATPase. The gastric H(+)/K(+) ATPase is responsible for the acidification of gastric juice and consists of an α subunit (H/Kα) and a β subunit (H/Kβ). Here we show that CD4(+) T cells from H/Kα-deficient mice (H/Kα(-/-)) are highly pathogenic and autoimmune...
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Full title
A Convenient Model of Severe, High Incidence Autoimmune Gastritis Caused by Polyclonal Effector T Cells and without Perturbation of Regulatory T Cells
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TN_cdi_plos_journals_1312159627
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1312159627
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0027153
