Structural Requirements for Yersinia YopJ Inhibition of MAP Kinase Pathways
Structural Requirements for Yersinia YopJ Inhibition of MAP Kinase Pathways
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United States: Public Library of Science
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English
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United States: Public Library of Science
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MAPK signaling cascades are evolutionally conserved. The bacterial effector, YopJ, uses the unique activity of Ser/Thr acetylation to inhibit the activation of the MAPK kinase (MKK) and prevent activation by phosphorylation. YopJ is also able to block yeast MAPK signaling pathways using this mechanism. Based on these observations, we performed a ge...
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Structural Requirements for Yersinia YopJ Inhibition of MAP Kinase Pathways
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TN_cdi_plos_journals_1312181639
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1312181639
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0001375
