The Role of IRE1α in the Degradation of Insulin mRNA in Pancreatic β-Cells
The Role of IRE1α in the Degradation of Insulin mRNA in Pancreatic β-Cells
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San Francisco: Public Library of Science
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English
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San Francisco: Public Library of Science
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Background The endoplasmic reticulum (ER) is a cellular compartment for the biosynthesis and folding of newly synthesized secretory proteins such as insulin. Perturbations to ER homeostasis cause ER stress and subsequently activate cell signaling pathways, collectively known as the Unfolded Protein Response (UPR). IRE1α is a central component of th...
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The Role of IRE1α in the Degradation of Insulin mRNA in Pancreatic β-Cells
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TN_cdi_plos_journals_1312184387
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1312184387
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0001648
