Genetic and Chemical Modifiers of a CUG Toxicity Model in Drosophila
Genetic and Chemical Modifiers of a CUG Toxicity Model in Drosophila
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Non-coding CUG repeat expansions interfere with the activity of human Muscleblind-like (MBNL) proteins contributing to myotonic dystrophy 1 (DM1). To understand this toxic RNA gain-of-function mechanism we developed a Drosophila model expressing 60 pure and 480 interrupted CUG repeats in the context of a non-translatable RNA. These flies reproduced...
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Genetic and Chemical Modifiers of a CUG Toxicity Model in Drosophila
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TN_cdi_plos_journals_1312186902
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1312186902
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0001595
