Exploring Off-Targets and Off-Systems for Adverse Drug Reactions via Chemical-Protein Interactome —...
Exploring Off-Targets and Off-Systems for Adverse Drug Reactions via Chemical-Protein Interactome — Clozapine-Induced Agranulocytosis as a Case Study
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Author / Creator
Yang, Lun , Wang, Kejian , Chen, Jian , Jegga, Anil G. , Luo, Heng , Shi, Leming , Wan, Chunling , Guo, Xizhi , Qin, Shengying , He, Guang , Feng, Guoyin and He, Lin
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
In the era of personalized medical practice, understanding the genetic basis of patient-specific adverse drug reaction (ADR) is a major challenge. Clozapine provides effective treatments for schizophrenia but its usage is limited because of life-threatening agranulocytosis. A recent high impact study showed the necessity of moving clozapine to a fi...
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Full title
Exploring Off-Targets and Off-Systems for Adverse Drug Reactions via Chemical-Protein Interactome — Clozapine-Induced Agranulocytosis as a Case Study
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TN_cdi_plos_journals_1313184920
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1313184920
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ISSN
1553-7358,1553-734X
E-ISSN
1553-7358
DOI
10.1371/journal.pcbi.1002016
