Consensus-Phenotype Integration of Transcriptomic and Metabolomic Data Implies a Role for Metabolism...
Consensus-Phenotype Integration of Transcriptomic and Metabolomic Data Implies a Role for Metabolism in the Chemosensitivity of Tumour Cells
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Contents
Using transcriptomic and metabolomic measurements from the NCI60 cell line panel, together with a novel approach to integration of molecular profile data, we show that the biochemical pathways associated with tumour cell chemosensitivity to platinum-based drugs are highly coincident, i.e. they describe a consensus phenotype. Direct integration of m...
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Consensus-Phenotype Integration of Transcriptomic and Metabolomic Data Implies a Role for Metabolism in the Chemosensitivity of Tumour Cells
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TN_cdi_plos_journals_1313185582
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1313185582
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ISSN
1553-7358,1553-734X
E-ISSN
1553-7358
DOI
10.1371/journal.pcbi.1001113
