Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and...
Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4
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Author / Creator
Libioulle, Cécile , Louis, Edouard , Hansoul, Sarah , Sandor, Cynthia , Farnir, Frédéric , Franchimont, Denis , Vermeire, Séverine , Dewit, Olivier , de Vos, Martine , Dixon, Anna , Demarche, Bruno , Gut, Ivo , Heath, Simon , Foglio, Mario , Liang, Liming , Laukens, Debby , Mni, Myriam , Zelenika, Diana , Van Gossum, André , Rutgeerts, Paul , Belaiche, Jacques , Lathrop, Mark and Georges, Michel
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publication information
Publisher
United States: Public Library of Science
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Scope and Contents
Contents
To identify novel susceptibility loci for Crohn disease (CD), we undertook a genome-wide association study with more than 300,000 SNPs characterized in 547 patients and 928 controls. We found three chromosome regions that provided evidence of disease association with p-values between 10(-6) and 10(-9). Two of these (IL23R on Chromosome 1 and CARD15...
Alternative Titles
Full title
Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4
Authors, Artists and Contributors
Author / Creator
Louis, Edouard
Hansoul, Sarah
Sandor, Cynthia
Farnir, Frédéric
Franchimont, Denis
Vermeire, Séverine
Dewit, Olivier
de Vos, Martine
Dixon, Anna
Demarche, Bruno
Gut, Ivo
Heath, Simon
Foglio, Mario
Liang, Liming
Laukens, Debby
Mni, Myriam
Zelenika, Diana
Van Gossum, André
Rutgeerts, Paul
Belaiche, Jacques
Lathrop, Mark
Georges, Michel
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1313474759
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1313474759
Other Identifiers
ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.0030058
