Why Do Hubs Tend to Be Essential in Protein Networks?
Why Do Hubs Tend to Be Essential in Protein Networks?
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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The protein-protein interaction (PPI) network has a small number of highly connected protein nodes (known as hubs) and many poorly connected nodes. Genome-wide studies show that deletion of a hub protein is more likely to be lethal than deletion of a non-hub protein, a phenomenon known as the centrality-lethality rule. This rule is widely believed...
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Why Do Hubs Tend to Be Essential in Protein Networks?
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TN_cdi_plos_journals_1313484724
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1313484724
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.0020088
