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Interactions between Cells with Distinct Mutations in c-MYC and Pten in Prostate Cancer

Interactions between Cells with Distinct Mutations in c-MYC and Pten in Prostate Cancer

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1313530350

Interactions between Cells with Distinct Mutations in c-MYC and Pten in Prostate Cancer

About this item

Full title

Interactions between Cells with Distinct Mutations in c-MYC and Pten in Prostate Cancer

Publisher

United States: Public Library of Science

Journal title

PLoS genetics, 2009-07, Vol.5 (7), p.e1000542-e1000542

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

In human somatic tumorigenesis, mutations are thought to arise sporadically in individual cells surrounded by unaffected cells. This contrasts with most current transgenic models where mutations are induced synchronously in entire cell populations. Here we have modeled sporadic oncogene activation using a transgenic mouse in which c-MYC is focally...

Alternative Titles

Full title

Interactions between Cells with Distinct Mutations in c-MYC and Pten in Prostate Cancer

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_1313530350

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1313530350

Other Identifiers

ISSN

1553-7404,1553-7390

E-ISSN

1553-7404

DOI

10.1371/journal.pgen.1000542

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