The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the...
The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines
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Author / Creator
Eizirik, Décio L. , Sammeth, Michael , Bouckenooghe, Thomas , Bottu, Guy , Sisino, Giorgia , Igoillo-Esteve, Mariana , Ortis, Fernanda , Santin, Izortze , Colli, Maikel L. , Barthson, Jenny , Bouwens, Luc , Hughes, Linda , Gregory, Lorna , Lunter, Gerton , Marselli, Lorella , Marchetti, Piero , McCarthy, Mark I. and Cnop, Miriam
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic beta cells are killed by infiltrating immune cells and by cytokines released by these cells. Signaling events occurring in the pancreatic beta cells are decisive for their survival or death in diabetes. We have used RNA sequencing (RNA-seq) to identify transcripts, including splice...
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Full title
The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines
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TN_cdi_plos_journals_1313531088
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1313531088
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1002552
