Common Genetic Variation and the Control of HIV-1 in Humans
Common Genetic Variation and the Control of HIV-1 in Humans
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Author / Creator
Fellay, Jacques , Ge, Dongliang , Shianna, Kevin V. , Colombo, Sara , Ledergerber, Bruno , Cirulli, Elizabeth T. , Urban, Thomas J. , Zhang, Kunlin , Gumbs, Curtis E. , Smith, Jason P. , Castagna, Antonella , Cozzi-Lepri, Alessandro , De Luca, Andrea , Easterbrook, Philippa , Günthard, Huldrych F. , Mallal, Simon , Mussini, Cristina , Dalmau, Judith , Martinez-Picado, Javier , Miro, José M. , Obel, Niels , Wolinsky, Steven M. , Martinson, Jeremy J. , Detels, Roger , Margolick, Joseph B. , Jacobson, Lisa P. , Descombes, Patrick , Antonarakis, Stylianos E. , Beckmann, Jacques S. , O'Brien, Stephen J. , Letvin, Norman L. , McMichael, Andrew J. , Haynes, Barton F. , Carrington, Mary , Feng, Sheng , Telenti, Amalio , Goldstein, David B. and NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI)
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publication information
Publisher
United States: Public Library of Science
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More information
Scope and Contents
Contents
To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associa...
Alternative Titles
Full title
Common Genetic Variation and the Control of HIV-1 in Humans
Authors, Artists and Contributors
Author / Creator
Ge, Dongliang
Shianna, Kevin V.
Colombo, Sara
Ledergerber, Bruno
Cirulli, Elizabeth T.
Urban, Thomas J.
Zhang, Kunlin
Gumbs, Curtis E.
Smith, Jason P.
Castagna, Antonella
Cozzi-Lepri, Alessandro
De Luca, Andrea
Easterbrook, Philippa
Günthard, Huldrych F.
Mallal, Simon
Mussini, Cristina
Dalmau, Judith
Martinez-Picado, Javier
Miro, José M.
Obel, Niels
Wolinsky, Steven M.
Martinson, Jeremy J.
Detels, Roger
Margolick, Joseph B.
Jacobson, Lisa P.
Descombes, Patrick
Antonarakis, Stylianos E.
Beckmann, Jacques S.
O'Brien, Stephen J.
Letvin, Norman L.
McMichael, Andrew J.
Haynes, Barton F.
Carrington, Mary
Feng, Sheng
Telenti, Amalio
Goldstein, David B.
NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI)
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1313535235
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1313535235
Other Identifiers
ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1000791
