Inactivation of a Novel FGF23 Regulator, FAM20C, Leads to Hypophosphatemic Rickets in Mice
Inactivation of a Novel FGF23 Regulator, FAM20C, Leads to Hypophosphatemic Rickets in Mice
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Family with sequence similarity 20,-member C (FAM20C) is highly expressed in the mineralized tissues of mammals. Genetic studies showed that the loss-of-function mutations in FAM20C were associated with human lethal osteosclerotic bone dysplasia (Raine Syndrome), implying an inhibitory role of this molecule in bone formation. However, in vitro gain...
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Inactivation of a Novel FGF23 Regulator, FAM20C, Leads to Hypophosphatemic Rickets in Mice
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TN_cdi_plos_journals_1313559765
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1313559765
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1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1002708
