Limited dCTP availability accounts for mitochondrial DNA depletion in mitochondrial neurogastrointes...
Limited dCTP availability accounts for mitochondrial DNA depletion in mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a severe human disease caused by mutations in TYMP, the gene encoding thymidine phosphorylase (TP). It belongs to a broader group of disorders characterized by a pronounced reduction in mitochondrial DNA (mtDNA) copy number in one or more tissues. In most cases, these disorders are ca...
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Full title
Limited dCTP availability accounts for mitochondrial DNA depletion in mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)
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TN_cdi_plos_journals_1313562311
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1313562311
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1002035
