The App-Runx1 Region Is Critical for Birth Defects and Electrocardiographic Dysfunctions Observed in...
The App-Runx1 Region Is Critical for Birth Defects and Electrocardiographic Dysfunctions Observed in a Down Syndrome Mouse Model
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Down syndrome (DS) leads to complex phenotypes and is the main genetic cause of birth defects and heart diseases. The Ts65Dn DS mouse model is trisomic for the distal part of mouse chromosome 16 and displays similar features with post-natal lethality and cardiovascular defects. In order to better understand these defects, we defined electrocardiogr...
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Full title
The App-Runx1 Region Is Critical for Birth Defects and Electrocardiographic Dysfunctions Observed in a Down Syndrome Mouse Model
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TN_cdi_plos_journals_1313572459
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1313572459
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1002724
