Common Genetic Variants and Modification of Penetrance of BRCA2-Associated Breast Cancer
Common Genetic Variants and Modification of Penetrance of BRCA2-Associated Breast Cancer
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Author / Creator
Gaudet, Mia M. , Kirchhoff, Tomas , Green, Todd , Vijai, Joseph , Korn, Joshua M. , Guiducci, Candace , Segrè, Ayellet V. , McGee, Kate , McGuffog, Lesley , Kartsonaki, Christiana , Morrison, Jonathan , Healey, Sue , Sinilnikova, Olga M. , Stoppa-Lyonnet, Dominique , Mazoyer, Sylvie , Gauthier-Villars, Marion , Sobol, Hagay , Longy, Michel , Frenay, Marc , GEMO Study Collaborators , Hogervorst, Frans B. L. , Rookus, Matti A. , Collée, J. Margriet , Hoogerbrugge, Nicoline , van Roozendaal, Kees E. P. , Piedmonte, Marion , Rubinstein, Wendy , Nerenstone, Stacy , Van Le, Linda , Blank, Stephanie V. , Caldés, Trinidad , de la Hoya, Miguel , Nevanlinna, Heli , Aittomäki, Kristiina , Lazaro, Conxi , Blanco, Ignacio , Arason, Adalgeir , Johannsson, Oskar T. , Barkardottir, Rosa B. , Devilee, Peter , Olopade, Olofunmilayo I. , Neuhausen, Susan L. , Wang, Xianshu , Fredericksen, Zachary S. , Peterlongo, Paolo , Manoukian, Siranoush , Barile, Monica , Viel, Alessandra , Radice, Paolo , Phelan, Catherine M. , Narod, Steven , Rennert, Gad , Lejbkowicz, Flavio , Flugelman, Anath , Andrulis, Irene L. , Glendon, Gord , Ozcelik, Hilmi , Toland, Amanda E. , Montagna, Marco , D'Andrea, Emma , Friedman, Eitan , Laitman, Yael , Borg, Ake , Beattie, Mary , Ramus, Susan J. , Domchek, Susan M. , Nathanson, Katherine L. , Rebbeck, Tim , Spurdle, Amanda B. , Chen, Xiaoqing , Holland, Helene , John, Esther M. , Hopper, John L. , Buys, Saundra S. , Daly, Mary B. , Southey, Melissa C. , Terry, Mary Beth , Tung, Nadine , Overeem Hansen, Thomas V. , Nielsen, Finn C. , Greene, Mark I. , Mai, Phuong L. , Osorio, Ana , Durán, Mercedes , Andres, Raquel , Benítez, Javier , Weitzel, Jeffrey N. , Garber, Judy , Hamann, Ute , Peock, Susan , Cook, Margaret , Oliver, Clare , Frost, Debra , Platte, Radka , Evans, D. Gareth , Lalloo, Fiona , Eeles, Ros , Izatt, Louise , Walker, Lisa , Eason, Jacqueline , HEBON Study Collaborators , kConFab , OCGN , EMBRACE , Faculty of Medicine , Department of Clinical Sciences, Lund , Medicinska fakulteten , Lund University , Bröstcancer-genetik , Institutionen för kliniska vetenskaper, Lund , Section I , Breastcancer-genetics , Lunds universitet and Sektion I
Publisher
United States: Public Library of Science (PLoS)
Journal title
Language
English
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Publisher
United States: Public Library of Science (PLoS)
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Contents
The considerable uncertainty regarding cancer risks associated with inherited mutations of BRCA2 is due to unknown factors. To investigate whether common genetic variants modify penetrance for BRCA2 mutation carriers, we undertook a two-staged genome-wide association study in BRCA2 mutation carriers. In stage 1 using the Affymetrix 6.0 platform, 59...
Alternative Titles
Full title
Common Genetic Variants and Modification of Penetrance of BRCA2-Associated Breast Cancer
Authors, Artists and Contributors
Author / Creator
Kirchhoff, Tomas
Green, Todd
Vijai, Joseph
Korn, Joshua M.
Guiducci, Candace
Segrè, Ayellet V.
McGee, Kate
McGuffog, Lesley
Kartsonaki, Christiana
Morrison, Jonathan
Healey, Sue
Sinilnikova, Olga M.
Stoppa-Lyonnet, Dominique
Mazoyer, Sylvie
Gauthier-Villars, Marion
Sobol, Hagay
Longy, Michel
Frenay, Marc
GEMO Study Collaborators
Hogervorst, Frans B. L.
Rookus, Matti A.
Collée, J. Margriet
Hoogerbrugge, Nicoline
van Roozendaal, Kees E. P.
Piedmonte, Marion
Rubinstein, Wendy
Nerenstone, Stacy
Van Le, Linda
Blank, Stephanie V.
Caldés, Trinidad
de la Hoya, Miguel
Nevanlinna, Heli
Aittomäki, Kristiina
Lazaro, Conxi
Blanco, Ignacio
Arason, Adalgeir
Johannsson, Oskar T.
Barkardottir, Rosa B.
Devilee, Peter
Olopade, Olofunmilayo I.
Neuhausen, Susan L.
Wang, Xianshu
Fredericksen, Zachary S.
Peterlongo, Paolo
Manoukian, Siranoush
Barile, Monica
Viel, Alessandra
Radice, Paolo
Phelan, Catherine M.
Narod, Steven
Rennert, Gad
Lejbkowicz, Flavio
Flugelman, Anath
Andrulis, Irene L.
Glendon, Gord
Ozcelik, Hilmi
Toland, Amanda E.
Montagna, Marco
D'Andrea, Emma
Friedman, Eitan
Laitman, Yael
Borg, Ake
Beattie, Mary
Ramus, Susan J.
Domchek, Susan M.
Nathanson, Katherine L.
Rebbeck, Tim
Spurdle, Amanda B.
Chen, Xiaoqing
Holland, Helene
John, Esther M.
Hopper, John L.
Buys, Saundra S.
Daly, Mary B.
Southey, Melissa C.
Terry, Mary Beth
Tung, Nadine
Overeem Hansen, Thomas V.
Nielsen, Finn C.
Greene, Mark I.
Mai, Phuong L.
Osorio, Ana
Durán, Mercedes
Andres, Raquel
Benítez, Javier
Weitzel, Jeffrey N.
Garber, Judy
Hamann, Ute
Peock, Susan
Cook, Margaret
Oliver, Clare
Frost, Debra
Platte, Radka
Evans, D. Gareth
Lalloo, Fiona
Eeles, Ros
Izatt, Louise
Walker, Lisa
Eason, Jacqueline
HEBON Study Collaborators
kConFab
OCGN
EMBRACE
Faculty of Medicine
Department of Clinical Sciences, Lund
Medicinska fakulteten
Lund University
Bröstcancer-genetik
Institutionen för kliniska vetenskaper, Lund
Section I
Breastcancer-genetics
Lunds universitet
Sektion I
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1313588518
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1313588518
Other Identifiers
ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1001183
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