Unlocking the Bottleneck in Forward Genetics Using Whole-Genome Sequencing and Identity by Descent t...
Unlocking the Bottleneck in Forward Genetics Using Whole-Genome Sequencing and Identity by Descent to Isolate Causative Mutations
About this item
Full title
Author / Creator
Bull, Katherine R. , Rimmer, Andrew J. , Siggs, Owen M. , Miosge, Lisa A. , Roots, Carla M. , Enders, Anselm , Bertram, Edward M. , Crockford, Tanya L. , Whittle, Belinda , Potter, Paul K. , Simon, Michelle M. , Mallon, Ann-Marie , Brown, Steve D. M. , Beutler, Bruce , Goodnow, Christopher C. , Lunter, Gerton and Cornall, Richard J.
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
Forward genetics screens with N-ethyl-N-nitrosourea (ENU) provide a powerful way to illuminate gene function and generate mouse models of human disease; however, the identification of causative mutations remains a limiting step. Current strategies depend on conventional mapping, so the propagation of affected mice requires non-lethal screens; accur...
Alternative Titles
Full title
Unlocking the Bottleneck in Forward Genetics Using Whole-Genome Sequencing and Identity by Descent to Isolate Causative Mutations
Authors, Artists and Contributors
Author / Creator
Rimmer, Andrew J.
Siggs, Owen M.
Miosge, Lisa A.
Roots, Carla M.
Enders, Anselm
Bertram, Edward M.
Crockford, Tanya L.
Whittle, Belinda
Potter, Paul K.
Simon, Michelle M.
Mallon, Ann-Marie
Brown, Steve D. M.
Beutler, Bruce
Goodnow, Christopher C.
Lunter, Gerton
Cornall, Richard J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1314342035
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1314342035
Other Identifiers
ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1003219
