Uncovering a Macrophage Transcriptional Program by Integrating Evidence from Motif Scanning and Expr...
Uncovering a Macrophage Transcriptional Program by Integrating Evidence from Motif Scanning and Expression Dynamics
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Author / Creator
Ramsey, Stephen A. , Klemm, Sandy L. , Zak, Daniel E. , Kennedy, Kathleen A. , Thorsson, Vesteinn , Li, Bin , Gilchrist, Mark , Gold, Elizabeth S. , Johnson, Carrie D. , Litvak, Vladimir , Navarro, Garnet , Roach, Jared C. , Rosenberger, Carrie M. , Rust, Alistair G. , Yudkovsky, Natalya , Aderem, Alan and Shmulevich, Ilya
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Macrophages are versatile immune cells that can detect a variety of pathogen-associated molecular patterns through their Toll-like receptors (TLRs). In response to microbial challenge, the TLR-stimulated macrophage undergoes an activation program controlled by a dynamically inducible transcriptional regulatory network. Mapping a complex mammalian t...
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Full title
Uncovering a Macrophage Transcriptional Program by Integrating Evidence from Motif Scanning and Expression Dynamics
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Record Identifier
TN_cdi_plos_journals_1314509597
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1314509597
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ISSN
1553-7358,1553-734X
E-ISSN
1553-7358
DOI
10.1371/journal.pcbi.1000021
