EMMPRIN Promotes Melanoma Cells Malignant Properties through a HIF-2alpha Mediated Up-Regulation of...
EMMPRIN Promotes Melanoma Cells Malignant Properties through a HIF-2alpha Mediated Up-Regulation of VEGF-Receptor-2
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
EMMPRIN's expression in melanoma tissue was reported to be predictive of poor prognosis. Here we demonstrate that EMMPRIN up-regulated VEGF receptor-2 (VEGFR-2) in two different primary melanoma cell lines and consequently increased migration and proliferation of these cells while inhibiting their apoptosis. SiRNA inhibition of VEGFR-2 expression a...
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Full title
EMMPRIN Promotes Melanoma Cells Malignant Properties through a HIF-2alpha Mediated Up-Regulation of VEGF-Receptor-2
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TN_cdi_plos_journals_1318931164
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1318931164
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0012265
