Mesenchymal stem cells promote mammosphere formation and decrease E-cadherin in normal and malignant...
Mesenchymal stem cells promote mammosphere formation and decrease E-cadherin in normal and malignant breast cells
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Author / Creator
Klopp, Ann H , Lacerda, Lara , Gupta, Anshul , Debeb, Bisrat G , Solley, Travis , Li, Li , Spaeth, Erika , Xu, Wei , Zhang, Xiaomei , Lewis, Michael T , Reuben, James M , Krishnamurthy, Savitri , Ferrari, Mauro , Gaspar, Rogério , Buchholz, Thomas A , Cristofanilli, Massimo , Marini, Frank , Andreeff, Michael and Woodward, Wendy A
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Normal and malignant breast tissue contains a rare population of multi-potent cells with the capacity to self-renew, referred to as stem cells, or tumor initiating cells (TIC). These cells can be enriched by growth as "mammospheres" in three-dimensional cultures.
We tested the hypothesis that human bone-marrow derived mesenchymal stem cells (MSC...
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Full title
Mesenchymal stem cells promote mammosphere formation and decrease E-cadherin in normal and malignant breast cells
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TN_cdi_plos_journals_1318936061
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1318936061
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0012180
