Activation of Wnt signaling by chemically induced dimerization of LRP5 disrupts cellular homeostasis
Activation of Wnt signaling by chemically induced dimerization of LRP5 disrupts cellular homeostasis
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Wnt signaling is crucial for a variety of biological processes, including body axis formation, planar polarity, stem cell maintenance and cellular differentiation. Therefore, targeted manipulation of Wnt signaling in vivo would be extremely useful. By applying chemical inducer of dimerization (CID) technology, we were able to modify the Wnt co-rece...
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Full title
Activation of Wnt signaling by chemically induced dimerization of LRP5 disrupts cellular homeostasis
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TN_cdi_plos_journals_1323440252
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1323440252
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0030814
