Radiosensitization of Normoxic and Hypoxic H1339 Lung Tumor Cells by Heat Shock Protein 90 Inhibitio...
Radiosensitization of Normoxic and Hypoxic H1339 Lung Tumor Cells by Heat Shock Protein 90 Inhibition Is Independent of Hypoxia Inducible Factor-1α
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Ionizing irradiation is a commonly accepted treatment modality for lung cancer patients. However, the clinical outcome is hampered by normal tissue toxicity and tumor hypoxia. Since tumors often have higher levels of active heat shock protein 90 (Hsp90) than normal tissues, targeting of Hsp90 might provide a promising strategy to sensitize tumors t...
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Radiosensitization of Normoxic and Hypoxic H1339 Lung Tumor Cells by Heat Shock Protein 90 Inhibition Is Independent of Hypoxia Inducible Factor-1α
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TN_cdi_plos_journals_1323558465
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1323558465
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0031110
