Ascl2 Knockdown Results in Tumor Growth Arrest by miRNA-302b-Related Inhibition of Colon Cancer Prog...
Ascl2 Knockdown Results in Tumor Growth Arrest by miRNA-302b-Related Inhibition of Colon Cancer Progenitor Cells
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Author / Creator
Zhu, Rong , Yang, Yongtao , Tian, Yin , Bai, Jianying , Zhang, Xin , Li, Xiaohuan , Peng, Zhihong , He, Yonghong , Chen, Lei , Pan, Qiong , Fang, Dianchun , Chen, Wensheng , Qian, Chen , Bian, Xiuwu and Wang, Rongquan
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Achaete scute-like 2 (Ascl2), a basic helix-loop-helix (bHLH) transcription factor, controls the fate of intestinal stem cells. However, the role of Ascl2 in colon cancer progenitor cells remains unknown. The cell line HT-29 (47.5-95% of CD133(+) population) and LS174T (0.45% of CD133(+) population) were chosen for functional evaluation of Ascl2 in...
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Full title
Ascl2 Knockdown Results in Tumor Growth Arrest by miRNA-302b-Related Inhibition of Colon Cancer Progenitor Cells
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TN_cdi_plos_journals_1323851054
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1323851054
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0032170
