Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activatio...
Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Switching to a glycolytic metabolism is a rapid adaptation of tumor cells to hypoxia. Although this metabolic conversion may primarily represent a rescue pathway to meet the bioenergetic and biosynthetic demands of proliferating tumor cells, it also creates a gradient of lactate that mirrors the gradient of oxygen in tumors. More than a metabolic w...
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Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis
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TN_cdi_plos_journals_1323996795
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1323996795
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0033418
