Genetics of Clusterin Isoform Expression and Alzheimer's Disease Risk
Genetics of Clusterin Isoform Expression and Alzheimer's Disease Risk
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United States: Public Library of Science
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English
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United States: Public Library of Science
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The minor allele of rs11136000 within CLU is strongly associated with reduced Alzheimer's disease (AD) risk. The mechanism underlying this association is unclear. Here, we report that CLU1 and CLU2 are the two primary CLU isoforms in human brain; CLU1 and CLU2 share exons 2-9 but differ in exon 1 and proximal promoters. The expression of both CLU1...
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Genetics of Clusterin Isoform Expression and Alzheimer's Disease Risk
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TN_cdi_plos_journals_1324444394
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1324444394
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0033923
