Antagonist effect of triptolide on AKT activation by truncated retinoid X receptor-alpha
Antagonist effect of triptolide on AKT activation by truncated retinoid X receptor-alpha
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Author / Creator
Lu, Na , Liu, Jinxing , Liu, Jie , Zhang, Chunyun , Jiang, Fuquan , Wu, Hua , Chen, Liqun , Zeng, Wenjun , Cao, Xihua , Yan, Tingdong , Wang, Guanghui , Zhou, Hu , Lin, Bingzhen , Yan, Xiaomei , Zhang, Xiao-kun and Zeng, Jin-Zhang
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Retinoid X receptor-alpha (RXRα) is a key member of the nuclear receptor superfamily. We recently demonstrated that proteolytic cleavage of RXRα resulted in production of a truncated product, tRXRα, which promotes cancer cell survival by activating phosphatidylinositol-3-OH kinase (PI3K)/AKT pathway. However, how the tRXRα-mediated signaling pathwa...
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Full title
Antagonist effect of triptolide on AKT activation by truncated retinoid X receptor-alpha
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TN_cdi_plos_journals_1324595482
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1324595482
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0035722
