Transient B cell depletion or improved transgene expression by codon optimization promote tolerance...
Transient B cell depletion or improved transgene expression by codon optimization promote tolerance to factor VIII in gene therapy
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
The major complication in the treatment of hemophilia A is the development of neutralizing antibodies (inhibitors) against factor VIII (FVIII). The current method for eradicating inhibitors, termed immune tolerance induction (ITI), is costly and protracted. Clinical protocols that prevent rather than treat inhibitors are not yet established. Liver-...
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Full title
Transient B cell depletion or improved transgene expression by codon optimization promote tolerance to factor VIII in gene therapy
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TN_cdi_plos_journals_1325008351
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1325008351
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0037671
