Isolation of Monoclonal Antibodies with Predetermined Conformational Epitope Specificity
Isolation of Monoclonal Antibodies with Predetermined Conformational Epitope Specificity
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Existing technologies allow isolating antigen-specific monoclonal antibodies (mAbs) from B cells. We devised a direct approach to isolate mAbs with predetermined conformational epitope specificity, using epitope mimetics (mimotopes) that reflect the three-dimensional structure of given antigen subdomains. We performed differential biopanning using...
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Full title
Isolation of Monoclonal Antibodies with Predetermined Conformational Epitope Specificity
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TN_cdi_plos_journals_1325027767
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1325027767
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0038943
