Anti-Tumour Effects of a Specific Anti-ADAM17 Antibody in an Ovarian Cancer Model In Vivo
Anti-Tumour Effects of a Specific Anti-ADAM17 Antibody in an Ovarian Cancer Model In Vivo
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United States: Public Library of Science
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English
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United States: Public Library of Science
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ADAM 17 (TNF-α converting enzyme, TACE) is a potential target for cancer therapy, but the small molecule inhibitors reported to date are not specific to this ADAM family member. This membrane-bound metalloproteinase is responsible for ectodomain shedding of pathologically significant substrates including TNF-α and EGFR ligands. The aim of this stud...
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Anti-Tumour Effects of a Specific Anti-ADAM17 Antibody in an Ovarian Cancer Model In Vivo
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TN_cdi_plos_journals_1325498503
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1325498503
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0040597
