Identification and Characterization of ZEL-H16 as a Novel Agonist of the Histamine H3 Receptor
Identification and Characterization of ZEL-H16 as a Novel Agonist of the Histamine H3 Receptor
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Shi, Ying , Sheng, Rong , Zhong, Tingting , Xu, Yu , Chen, Xiaopan , Yang, Dong , Sun, Yi , Yang, Fenyan , Hu, Yongzhou and Zhou, Naiming
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
The histamine H3 receptor (H3R) has been recognized as a promising target for the treatment of various central and peripheral nervous system diseases. In this study, a non-imidazole compound, ZEL-H16, was identified as a novel histamine H3 receptor agonist. ZEL-H16 was found to bind to human H3R with a Ki value of approximately 2.07 nM and 4.36 nM...
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Full title
Identification and Characterization of ZEL-H16 as a Novel Agonist of the Histamine H3 Receptor
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TN_cdi_plos_journals_1326222767
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1326222767
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0042185
