A small molecule agonist of EphA2 receptor tyrosine kinase inhibits tumor cell migration in vitro an...
A small molecule agonist of EphA2 receptor tyrosine kinase inhibits tumor cell migration in vitro and prostate cancer metastasis in vivo
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
During tumor progression, EphA2 receptor can gain ligand-independent pro-oncogenic functions due to Akt activation and reduced ephrin-A ligand engagement. The effects can be reversed by ligand stimulation, which triggers the intrinsic tumor suppressive signaling pathways of EphA2 including inhibition of PI3/Akt and Ras/ERK pathways. These observati...
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Full title
A small molecule agonist of EphA2 receptor tyrosine kinase inhibits tumor cell migration in vitro and prostate cancer metastasis in vivo
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TN_cdi_plos_journals_1326241956
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1326241956
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0042120
