Tyrosinase Degradation Is Prevented when EDEM1 Lacks the Intrinsically Disordered Region
Tyrosinase Degradation Is Prevented when EDEM1 Lacks the Intrinsically Disordered Region
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
EDEM1 is a mannosidase-like protein that recruits misfolded glycoproteins from the calnexin/calreticulin folding cycle to downstream endoplasmic reticulum associated degradation (ERAD) pathway. Here, we investigate the role of EDEM1 in the processing of tyrosinase, a tumour antigen overexpressed in melanoma cells. First, we analyzed and modeled EDE...
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Full title
Tyrosinase Degradation Is Prevented when EDEM1 Lacks the Intrinsically Disordered Region
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TN_cdi_plos_journals_1326543827
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1326543827
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0042998
