PTEN/Akt signaling controls mitochondrial respiratory capacity through 4E-BP1
PTEN/Akt signaling controls mitochondrial respiratory capacity through 4E-BP1
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Akt, a serine/threonine kinase has been shown to stimulate glycolysis in cancer cells but its role in mitochondrial respiration is unknown. Using PTEN-knockout mouse embryonic fibroblasts (MEF(PTEN-/-)) with hyper-activated Akt as a cell model, we observed a higher respiratory capacity in MEF(PTEN-/-) compared to the wildtype (MEF(WT)). The respira...
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Full title
PTEN/Akt signaling controls mitochondrial respiratory capacity through 4E-BP1
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TN_cdi_plos_journals_1326551640
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1326551640
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0045806
