Poly(ADP-ribosyl)ation acts in the DNA demethylation of mouse primordial germ cells also with DNA da...
Poly(ADP-ribosyl)ation acts in the DNA demethylation of mouse primordial germ cells also with DNA damage-independent roles
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Poly(ADP-ribosyl)ation regulates chromatin structure and transcription driving epigenetic events. In particular, Parp1 is able to directly influence DNA methylation patterns controlling transcription and activity of Dnmt1. Here, we show that ADP-ribose polymer levels and Parp1 expression are noticeably high in mouse primordial germ cells (PGCs) whe...
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Full title
Poly(ADP-ribosyl)ation acts in the DNA demethylation of mouse primordial germ cells also with DNA damage-independent roles
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TN_cdi_plos_journals_1326720534
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1326720534
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0046927
