Activation of Haem-Oxidized Soluble Guanylyl Cyclase with BAY 60-2770 in Human Platelets Lead to Ove...
Activation of Haem-Oxidized Soluble Guanylyl Cyclase with BAY 60-2770 in Human Platelets Lead to Overstimulation of the Cyclic GMP Signaling Pathway
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Nitric oxide-independent soluble guanylyl cyclase (sGC) activators reactivate the haem-oxidized enzyme in vascular diseases. This study was undertaken to investigate the anti-platelet mechanisms of the haem-independent sGC activator BAY 60-2770 in human washed platelets. The hypothesis that sGC oxidation potentiates the anti-platelet activities of...
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Full title
Activation of Haem-Oxidized Soluble Guanylyl Cyclase with BAY 60-2770 in Human Platelets Lead to Overstimulation of the Cyclic GMP Signaling Pathway
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TN_cdi_plos_journals_1326725138
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1326725138
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0047223
