Inhibition of Tankyrases Induces Axin Stabilization and Blocks Wnt Signalling in Breast Cancer Cells
Inhibition of Tankyrases Induces Axin Stabilization and Blocks Wnt Signalling in Breast Cancer Cells
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Constitutive Wnt signalling is characterized by excessive levels of β-catenin protein and is a frequent occurrence in cancer. APC and Axin are key components of the β-catenin destruction complex that acts to promote β-catenin degradation. The levels of Axin are in turn controlled by tankyrases, members of the PARP-family of poly-ADP-ribosylation en...
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Inhibition of Tankyrases Induces Axin Stabilization and Blocks Wnt Signalling in Breast Cancer Cells
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TN_cdi_plos_journals_1326737783
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1326737783
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0048670
