Synergistic effects of combined Wnt/KRAS inhibition in colorectal cancer cells
Synergistic effects of combined Wnt/KRAS inhibition in colorectal cancer cells
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Activation of Wnt signalling due to inability to degrade β-catenin is found in >85% of colorectal cancers. Approximately half of colon cancers express a constitutively active KRAS protein. A significant fraction of patients show both abnormalities. We previously reported that simultaneous down-regulation of both β-catenin and KRAS was necessary to...
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Full title
Synergistic effects of combined Wnt/KRAS inhibition in colorectal cancer cells
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TN_cdi_plos_journals_1326749112
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1326749112
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0051449
