PARP-1 modulation of mTOR signaling in response to a DNA alkylating agent
PARP-1 modulation of mTOR signaling in response to a DNA alkylating agent
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Poly(ADP-ribose) polymerase-1 (PARP-1) is widely involved in cell death responses. Depending on the degree of injury and on cell type, PARP activation may lead to autophagy, apoptosis or necrosis. In HEK293 cells exposed to the alkylating agent N-methyl-N'-nitro-N'-nitrosoguanine (MNNG), we show that PARP-1 activation triggers a necrotic cell death...
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Full title
PARP-1 modulation of mTOR signaling in response to a DNA alkylating agent
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TN_cdi_plos_journals_1327131176
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1327131176
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0047978
