The clinically-tested S1P receptor agonists, FTY720 and BAF312, demonstrate subtype-specific bradyca...
The clinically-tested S1P receptor agonists, FTY720 and BAF312, demonstrate subtype-specific bradycardia (S1P₁) and hypertension (S1P₃) in rat
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Sphingosine-1-phospate (S1P) and S1P receptor agonists elicit mechanism-based effects on cardiovascular function in vivo. Indeed, FTY720 (non-selective S1P(X) receptor agonist) produces modest hypertension in patients (2-3 mmHg in 1-yr trial) as well as acute bradycardia independent of changes in blood pressure. However, the precise receptor subtyp...
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Full title
The clinically-tested S1P receptor agonists, FTY720 and BAF312, demonstrate subtype-specific bradycardia (S1P₁) and hypertension (S1P₃) in rat
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TN_cdi_plos_journals_1327231340
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1327231340
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0052985
