Resistance after chronic application of the HDAC-inhibitor valproic acid is associated with elevated...
Resistance after chronic application of the HDAC-inhibitor valproic acid is associated with elevated Akt activation in renal cell carcinoma in vivo
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Targeted drugs have significantly improved the therapeutic options for advanced renal cell carcinoma (RCC). However, resistance often develops, negating the benefit of these agents. In the present study, the molecular mechanisms of acquired resistance towards the histone deacetylase (HDAC) inhibitor valproic acid (VPA) in a RCC in vivo model were i...
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Full title
Resistance after chronic application of the HDAC-inhibitor valproic acid is associated with elevated Akt activation in renal cell carcinoma in vivo
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TN_cdi_plos_journals_1327778909
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1327778909
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0053100
