Cysteine depletion causes oxidative stress and triggers outer membrane vesicle release by Neisseria...
Cysteine depletion causes oxidative stress and triggers outer membrane vesicle release by Neisseria meningitidis; implications for vaccine development
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Outer membrane vesicles (OMV) contain immunogenic proteins and contribute to in vivo survival and virulence of bacterial pathogens. The first OMV vaccines successfully stopped Neisseria meningitidis serogroup B outbreaks but required detergent-extraction for endotoxin removal. Current vaccines use attenuated endotoxin, to preserve immunological pro...
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Full title
Cysteine depletion causes oxidative stress and triggers outer membrane vesicle release by Neisseria meningitidis; implications for vaccine development
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TN_cdi_plos_journals_1327799952
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1327799952
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0054314
