Integrating High-Content Imaging and Chemical Genetics to Probe Host Cellular Pathways Critical for...
Integrating High-Content Imaging and Chemical Genetics to Probe Host Cellular Pathways Critical for Yersinia Pestis Infection
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
The molecular machinery that regulates the entry and survival of Yersinia pestis in host macrophages is poorly understood. Here, we report the development of automated high-content imaging assays to quantitate the internalization of virulent Y. pestis CO92 by macrophages and the subsequent activation of host NF-κB. Implementation of these assays in...
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Full title
Integrating High-Content Imaging and Chemical Genetics to Probe Host Cellular Pathways Critical for Yersinia Pestis Infection
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TN_cdi_plos_journals_1327979542
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1327979542
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0055167
