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Properties and Molecular Determinants of the Natural Flavone Acacetin for Blocking hKv4.3 Channels

Properties and Molecular Determinants of the Natural Flavone Acacetin for Blocking hKv4.3 Channels

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1330882366

Properties and Molecular Determinants of the Natural Flavone Acacetin for Blocking hKv4.3 Channels

About this item

Full title

Properties and Molecular Determinants of the Natural Flavone Acacetin for Blocking hKv4.3 Channels

Publisher

United States: Public Library of Science

Journal title

PloS one, 2013-03, Vol.8 (3), p.e57864

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

The natural flavone acacetin has been demonstrated to inhibit transient outward potassium current (Ito) in human atrial myocytes. However, the molecular determinants of acacetin for blocking Ito are unknown. The present study was designed to investigate the properties and molecular determinants of this compound for blocking hKv4.3 channels (coding...

Alternative Titles

Full title

Properties and Molecular Determinants of the Natural Flavone Acacetin for Blocking hKv4.3 Channels

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_1330882366

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1330882366

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0057864

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