Kinetic and Structural Evidences on Human Prolidase Pathological Mutants Suggest Strategies for Enzy...
Kinetic and Structural Evidences on Human Prolidase Pathological Mutants Suggest Strategies for Enzyme Functional Rescue
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Prolidase is the only human enzyme responsible for the digestion of iminodipeptides containing proline or hydroxyproline at their C-terminal end, being a key player in extracellular matrix remodeling. Prolidase deficiency (PD) is an intractable loss of function disease, characterized by mutations in the prolidase gene. The exact causes of activity...
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Kinetic and Structural Evidences on Human Prolidase Pathological Mutants Suggest Strategies for Enzyme Functional Rescue
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TN_cdi_plos_journals_1330898349
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1330898349
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0058792
