Knockdown of HPRT for Selection of Genetically Modified Human Hematopoietic Progenitor Cells
Knockdown of HPRT for Selection of Genetically Modified Human Hematopoietic Progenitor Cells
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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The inability to obtain sufficient numbers of transduced cells remains a limitation in gene therapy. One strategy to address this limitation is in vivo pharmacologic selection of transduced cells. We have previously shown that knockdown of HPRT using lentiviral delivered shRNA facilitates efficient selection of transduced murine hematopoietic proge...
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Full title
Knockdown of HPRT for Selection of Genetically Modified Human Hematopoietic Progenitor Cells
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TN_cdi_plos_journals_1330898856
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1330898856
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0059594
