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Impact of the herbal medicine Sophora flavescens on the oral pharmacokinetics of indinavir in rats:...

Impact of the herbal medicine Sophora flavescens on the oral pharmacokinetics of indinavir in rats:...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1332847448

Impact of the herbal medicine Sophora flavescens on the oral pharmacokinetics of indinavir in rats: the involvement of CYP3A and P-glycoprotein

About this item

Full title

Impact of the herbal medicine Sophora flavescens on the oral pharmacokinetics of indinavir in rats: the involvement of CYP3A and P-glycoprotein

Publisher

United States: Public Library of Science

Journal title

PloS one, 2012-02, Vol.7 (2), p.e31312

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

Sophora flavescens is a Chinese medicinal herb used for the treatment of gastrointestinal hemorrhage, skin diseases, pyretic stranguria and viral hepatitis. In this study the herb-drug interactions between S. flavescens and indinavir, a protease inhibitor for HIV treatment, were evaluated in rats. Concomitant oral administration of Sophora extract...

Alternative Titles

Full title

Impact of the herbal medicine Sophora flavescens on the oral pharmacokinetics of indinavir in rats: the involvement of CYP3A and P-glycoprotein

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_1332847448

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1332847448

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0031312

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