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The C-Type Lectin of the Aggrecan G3 Domain Activates Complement

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The C-Type Lectin of the Aggrecan G3 Domain Activates Complement

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1335051370

The C-Type Lectin of the Aggrecan G3 Domain Activates Complement

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United States: Public Library of Science

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Contents

Excessive complement activation contributes to joint diseases such as rheumatoid arthritis and osteoarthritis during which cartilage proteins are fragmented and released into the synovial fluid. Some of these proteins and fragments activate complement, which may sustain inflammation. The G3 domain of large cartilage proteoglycan aggrecan interacts...

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The C-Type Lectin of the Aggrecan G3 Domain Activates Complement

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Record Identifier

TN_cdi_plos_journals_1335051370

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1335051370

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ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0061407

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