Mitotic Spindle Defects and Chromosome Mis-Segregation Induced by LDL/Cholesterol—Implications for N...
Mitotic Spindle Defects and Chromosome Mis-Segregation Induced by LDL/Cholesterol—Implications for Niemann-Pick C1, Alzheimer’s Disease, and Atherosclerosis
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Elevated low-density lipoprotein (LDL)-cholesterol is a risk factor for both Alzheimer's disease (AD) and Atherosclerosis (CVD), suggesting a common lipid-sensitive step in their pathogenesis. Previous results show that AD and CVD also share a cell cycle defect: chromosome instability and up to 30% aneuploidy-in neurons and other cells in AD and in...
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Full title
Mitotic Spindle Defects and Chromosome Mis-Segregation Induced by LDL/Cholesterol—Implications for Niemann-Pick C1, Alzheimer’s Disease, and Atherosclerosis
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TN_cdi_plos_journals_1335051445
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1335051445
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0060718
